Beyond Semaglutide & Tirzepatide: Alternative Medications That Support Weight Management

At Elite Mei, we offer a full spectrum of clinically proven alternatives that can help support your weight loss journey—especially as semaglutide and tirzepatide are now off the FDA’s shortage list.

But here’s the truth: not everyone is a candidate for GLP-1 receptor agonists. And even for those who are, these medications don’t work for everyone. In fact, studies show that 18–20% of people may not respond to GLP-1 medications at all. That’s why having a personalized, holistic approach to weight management is so important—and it’s exactly what we offer at Elite Mei.

Why GLP-1s Aren’t for Everyone

GLP-1 receptor agonists are powerful tools, but they aren't universally suitable. Reasons someone might not be a candidate include:

• Underlying medical conditions (such as a history of pancreatitis, certain thyroid disorders, or gallbladder disease)

• Severe gastrointestinal side effects (nausea, vomiting, or constipation that can impact quality of life)

• Medication interactions or contraindications

• Pregnancy or breastfeeding

• Non-responsiveness to the medication, despite appropriate dosing and adherence

Rather than feeling discouraged, it’s crucial to know there are effective alternatives that can still help you move toward your weight loss goals—safely and sustainably.

What Are the Other Options for Weight Loss Medications?

At Elite Mei, our providers are trained to evaluate your unique health profile and recommend the most appropriate, evidence-based treatment plan. For those who aren’t candidates for GLP-1s—or are looking for combination therapy—our doctor may recommend:

1. Phentermine

One of the most commonly prescribed weight loss medications, phentermine is an FDA-approved appetite suppressant that can help jumpstart weight loss. It’s especially effective when paired with behavioral changes and physician support.

2. Topiramate

Often used in combination with phentermine (as in the FDA-approved medication Qsymia®), topiramate can support weight loss by increasing satiety and reducing appetite. It may also help regulate cravings and binge eating.

3. Bupropion/Naltrexone (Contrave®)

This combination medication works on the brain’s reward system to reduce cravings and regulate hunger. It’s a good option for those who struggle with emotional or stress-related eating.

4. Metformin

While primarily used for blood sugar management, metformin has weight-reducing effects in certain individuals, particularly those with insulin resistance or PCOS.

Personalized Treatment Matters

No two bodies are the same—and no one medication is right for everyone. At Elite Mei, we believe in personalized medicine, and our weight management programs are designed around your:

• Medical history

• Lab results

• Lifestyle

• Goals

• Response to treatment

If you’ve tried GLP-1s and didn’t respond—or were told you aren’t a candidate—you still have options.

Let’s Find What Works for You

Our mission at Elite Mei is to help you achieve your healthiest, most confident self with science-backed, compassionate care. Whether you’re exploring GLP-1 alternatives or just beginning your weight loss journey, our expert team is here to guide you every step of the way.

📅 Book a consultation today to see which medications or treatments are right for you—and start your journey with a team that listens, supports, and personalizes every plan.

Elite Mei | Medically Supervised Weight Management in Woodside, NY

Your path to sustainable wellness starts here.